THE EFFECT OF ARABIC COFFEE (Coffea arabica L.) SEED EXTRACT ADMINISTRATION ON STOMACH HISTOPATHOLOGY OF ALBINO WISTAR RAT

Tovani, Sri and Rani, Rubiyanti (2020) THE EFFECT OF ARABIC COFFEE (Coffea arabica L.) SEED EXTRACT ADMINISTRATION ON STOMACH HISTOPATHOLOGY OF ALBINO WISTAR RAT. Fitofarmaka Jurnal Ilmiah Farmasi, 10 (1). pp. 32-41. ISSN 2087-9164

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Official URL: https://journal.unpak.ac.id/index.php/fitofarmaka/...

Abstract

Among all the content contained in coffee, caffeine is best known. Caffeine when consumed excessively can increase muscle tension, stimulate heart work, and increase the secretion of gastric acid. Ulcers can occur in the mucosa, submucosa and until the musculoskeletal lining of the gastrointestinal tractus is associated with gastric acid that contains HCl. This study aims to determine the influence of arabica coffee bean extract (Coffea arabica L.) against histopathology of the stomach of the white rats Wistar strain. The Arabica coffee bean extract test material is obtained from the extraction of arabica coffee beans done by Soxhlet method using ethanol 70%. The test animal used in the study was a 25 Wistar strain rats that consisted of negative control groups (not given treatment), positive control (aspirin-induced 30 mg/kg bw rats) as a comparator, extract coffee bean ethanol dose I (0.12 g/kg bw rats), Dose II (0.24 g/kg bw rats), and dose III (0.48 g/kg bw rats), within 30 days. Results showed on rats histopathology which is given ethanol coffee extract dose I there is a similar picture to the negative control group i.e. the normal gastric picture. Histopathology of rat Gastric Wistar Group IV given ethanol coffee extract dose II indicates the presence of slight lymphocytes, edema, and capillary dilation. The administration of coffee bean ethanol extract dose III caused the presence of damage to the stomach, similar histopathology changes in the aspirininduced positive control group.

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